However, the expressions of CYP4B1 in various cancers and hence their potential roles in cancer development were inclusive.
Its predominant extrahepatic expression has been associated with certain tissue-specific toxicities. “ In the coming months, we will see interesting data from some companies in our space.Cytochrome P450 4B1 (CYP4B1) plays crucial roles in biotransforming of xenobiotics. “ Gene and cell therapies are mature and can move from version 1.0 to 2.0, from rare diseases to cancer and autoimmune diseases,” said Paracchi.
Furthermore, gene therapy technology is likely to see a major shift as it becomes more mainstream. However, he added that Genflow’s longevity angle could make it easier to keep investors engaged than for other public gene therapy developers.Īlthough the outlook remains gloomy for many biotech stocks, Paracchi sees a strong season coming for mergers and acquisitions as big investors take advantage of the discounted prices. “ This early work on process development and chemistry, manufacturing, and control is difficult to communicate to the public, which is expecting some quick efficacy proof of concept,” said Leire. This process can be tough to convey to impatient stock markets. “ We believe that now we are reaching the tipping point where gene delivery can be safely administered at a reasonable cost.”Īs the technology is still maturing, companies developing these treatments must invest heavily in manufacturing and preclinical work early on. “ Everything is in the details,” said Leire. Nonetheless, knowledge of gene therapy and safe use of its most common delivery method - viral vectors - is growing. Over the last few years, many gene therapy players including BioMarin, Rocket Pharmaceuticals, Astellas, and bluebird bio have encountered safety issues that led to pauses in clinical development and stock price drops.
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